Estimating the 10-year fracture risk among persons with HIV and person without HIV: A comparative study

Faculty of Nursing UNPAD Study Reveals Higher 10-Year Fracture Risk in People with HIV

Researchers from the Faculty of Nursing, Universitas Padjadjaran (UNPAD), in collaboration with international partners, have conducted a comparative study estimating the 10-year fracture risk between persons with HIV and those without HIV using the FRAX™ algorithm. The findings, published in the Jurnal Keperawatan Padjadjaran, highlight important implications for osteoporosis prevention and management, particularly among high-risk populations.

The study, led by Iqbal Pramukti, S.Kep.,Ners.,M.Sc., Ph.D., along with Prof. Kusman Ibrahim,S.Kp.,MNS.,Ph.D., Mamat Lukman,S.Kp., SKM.,M.Si. , Hasniatisari Harun, S.Kep.,Ners.,M.Kep., Andri Nugraha, and Chung-Ying Lin, involved 221 participants107 with HIV and 114 without HIV, recruited between August and November 2023. The results showed that the average 10-year probability of major osteoporotic fracture (MOF) was 3.1% in the HIV group and 2.7% in the non-HIV group. For hip fractures (HF), the probability was 0.5% for HIV and 0.6% for non-HIV.

While the overall risk differences were modest, specific factors such as fracture history, smoking, and glucocorticoid use were linked to higher fracture probabilities. Notably, individuals with HIV who had a history of fractures exhibited lower MOF scores than their non-HIV counterparts, while those with glucocorticoid use recorded slightly higher MOF scores.

This research underscores the need for targeted fracture prevention programs for people living with HIV, integrating lifestyle modification, medication review, and routine bone health assessments. The findings support SDG 3: Good Health and Well-being by promoting proactive management of chronic conditions, and SDG 4: Quality Education by fostering evidence-based nursing education and clinical practice.

Full article: https://doi.org/10.24198/jkp.v13i1.2715